Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines

作者：Kojima Naoto^*; Suga Yuki; Hayashi Hiromi; Yamori Takao; Yoshimitsu Takehiko; Tanaka Tetsuaki

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(19): 5745-5749.

DOI：10.1016/j.bmcl.2011.08.011

• Annonaceous acetogenin
• Structure-activity relationship
• Antitumor agent
• Fluorinated analogue
• Chemical synthesis

The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated gamma-lactone fragment. It was revealed that the number of fluorine atoms on the gamma-lactone moiety affects the growth inhibitory activities against human cancer cell lines.

• 出版日期2011-10-1