NMDA receptor-dependent long-term potentiation is dependent on low-voltage-activated calcium currents in the sensorimotor cortex of cats

作者：Kitagawa H^*; Inoue K; Nishida A; Nishimura Y; Yamamoto T; Nishimura Y

来源：Brain Research, 2004, 1008(1): 116-119.

DOI：10.1016/j.brainres.2004.01.024

• low-threshold
• T type
• Ca2+
• long-term depression
• motor cortex
• pyramidal neuron

The role of low-voltage-activated (LVA) calcium channels in the expression of long-term potentiation (LTP) was examined by intracellular recording in slices front car agranular cortex. In the normal solution, LTP was induced, and the potentiation of low-threshold rebound potential was evoked by negative current injection. In the cells, in which resting membrane potential was depolarized, the incidence of LTP was very low. LTP was blocked completely in the presence of NMDA receptor antagonist or 50-100 muM nickel. It was suggested that LVA calcium channels function downstrearn of NMDA receptor-dependent signaling.

• 出版日期2004-5-15