High efficacy of anti DBL4 epsilon-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

作者：Magistrado Pamela A; Minja Daniel; Doritchamou Justin; Ndam Nicaise Tuikue; John Davis; Schmiegelow Christentze; Massougbodji Achille; Dahlback Madeleine; Ditlev Sisse B; Pinto Vera V; Resende Mafalda; Lusingu John; Theander Thor G; Salanti Ali; Nielsen Morten A^*

来源：Vaccine, 2011, 29(3): 437-443.

DOI：10.1016/j.vaccine.2010.10.080

• Placental malaria
• VAR2CSA
• Vaccine
• Plasmodium falciparum

Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4 epsilon from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4 epsilon recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.

• 出版日期2011-1-10