Antioxidant phenylpropanoid glycosides from Buddleja davidii

作者：Ahmad, Ijaz^*; Ahmad, Nisar; Wang, Fanghai

来源：Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24(4): 993-997.

DOI：10.1080/14756360802565072

• Buddleja davidii
• Buddlejaceae
• phenylpropanoid glycosides
• antioxidant
• Buddleia

Phytochemical investigations on the n-BuOH-soluble fraction of the whole plant of Buddleja davidii led to the isolation of the phenylpropanoid glycosides 1-10. Their structures were determined by 1D and 2D NMR spectroscopic techniques. All the compounds showed potent antioxidative activity in three different tests, with IC50 values in the range 4.15-9.47 mu M in the hydroxyl radical ((OH)-O-center dot) inhibitory activity test, 40.32-81.15 mu M in the total ROS (reactive oxygen species) inhibitory activity test, and 2.26-7.79 mu M in the peroxynitrite (ONOO-) scavenging activity test. Calceolarioside A (1) displayed the strongest scavenging potential with IC50 values of (4.15 /- 0.07, 40.32 /- 0.09, 2.26 /- 0.03 mu M) for (OH)-O-center dot, total ROS and scavenging of ONOO-, respectively.

• 出版日期2009-8
• 单位中山大学