Nasal irrigation reduces postirradiation rhinosinusitis in patients with nasopharyngeal carcinoma

作者：Liang Kai Li; Kao Ta Cheng; Lin Jin Ching; Tseng Hung Cheng; Su Mao Chang; Hsin Chung Han; Shiao Jiun Yih; Jiang Rong San^*

来源：American Journal of Rhinology, 2008, 22(3): 258-262.

DOI：10.2500/ajr.2008.22.3166

• cancer
• complication
• intensity-modulated radiotherapy
• nasal douching
• nasal irrigation
• nasopharyngeal carcinoma
• paranasal sinus diseases
• radiotherapy
• randomized
• rhinosinusitis

Background: Nasopharyngeal carcinoma (NPC) is a common head and neck cancer in Taiwan. Radiotherapy (RT) is the standard treatment for NPC. The newer RT technique, intensity-modulated radiotherapy (IMRT) has become popular in recent years. IMRT-induced rhinosinusitis is not uncommon in postirradiated NPC patients but the incidence and the disease course have not been reported. The purpose of this study was to determine the IMRT effect on the paranasal sinuses and evaluate the efficacy of nasal irrigation on the management of RT-induced rhinosinusitis.
Methods: NPC patients who completed IMRT from October 2004 to May 2006 were enrolled in the study and were randomly allocated to irrigation or nonirrigation groups. Patients in the irrigation group performed daily nasal irrigation until 6 months after RT. The severity of postirradiated rhinosinusitis was evaluated by nasal endoscopy, questionnaire, and computed tomography until a year after RT.
Results: One hundred seven postirradiated NPC patients completed the study. Among them, 44 patients performed daily nasal irrigation until 6 months after RT, and the other 63 patients did not perform nasal irrigation after RT. Patients in the irrigation group had significantly lower endoscopic and questionnaire scores than patients in the nonirrigation group (p = 0.001 and 0.0001, respectively) from pre-RT to 6 months after RT. The between-group differences were most obvious at the post-RT second and third months.
Conclusion: Rhinosinusitis is a common acute post-RT complication in NPC patients. Our results showed that nasal irrigation was a safe and effective method for the management of this acute complication.

• 出版日期2008-6
• 单位中国医科大学