Alginic acid: A mild and renewable bifunctional heterogeneous biopolymeric organocatalyst for efficient and facile synthesis of polyhydroquinolines

作者：Dekamin Mohammad G^*; Karimi Zahra; Latifidoost Zahra; Ilkhanizadeh Siamand; Daemi Hamed; Naimi Jamal M Reza; Barikani Mehdi

来源：International Journal of Biological Macromolecules, 2018, 108: 1273-1280.

DOI：10.1016/j.ijbiomac.2017.11.050

• Alginic acid
• Biopolymer
• Organocatalysis
• Polyhydroquinolines (PHQs)
• Hantzsch esters
• Heterocycles
• Green chemistry

Alginic acid, a widely used naturally occurring carbohydrate which is generally derived from brown seaweeds, can be considered as a bifunctional heterogeneous and green biopolymeric organocatalyst. Alginic acid, without any post-modification with active Bronsted or Lewis acid centers, was found to be a highly active, cost-effective, commercially-available, renewable and recoverable heterogeneous biopolymeric organocatalyst for the expeditious synthesis of polyhydroquinolines (PHQs). Polyhydroquinolines were synthesized from the four-component Hantzsch reaction of ethyl acetoacetate, different aldehydes, ammonium acetate and cyclic 1,3-diones under mild conditions in high to quantitative yields, 75-97%, using alginic acid. Furthermore, alginic acid was found to be reusable for at least 6 consecutive cycles without considerable loss of its catalytic activity.

• 出版日期2018-3