A Formal [5+1] Annulation Reaction of Sulfur Ylides and 2-(1H-indol-2-yl)phenols: Access to Indole-Fused 4H-benzo[e][1,3]oxazines

作者：Jia, Penghao; Huang, You^*

来源：Advanced Synthesis & Catalysis, 2018, 360(16): 3044-3048.

DOI：10.1002/adsc.201800573

• prop-2-ynylsulfonium salts
• annulation
• C1 synthon
• thioether
• sulfur ylide

The first sulfur ylides involved formal [5+1]-annulation reaction was developed between prop-2-ynylsulfonium salts and 2-(1H-indol-2-yl)phenols. Prop-2-ynylsulfonium salt participates in the reaction with its -carbon atom and acts as a novel C-1 synthon. Various indole-fused 4H-benzo[e][1,3]oxazines bearing a thioether moiety were constructed in good to high yields under mild conditions.

• 出版日期2018-8-17
• 单位南开大学