A simple and effective strategy for the directed and high-yield assembly of large-sized gold nanoparticles driven by bithiol-modified complementary dsDNA architectures

作者：Cheng, Yan-Fang; Yu, Gui-Ping; Yan, Yuan; Liu, Jian-Yu; Ye, Cui; Yu, Xiang^*; Lai, Xuan-Di; Hu, Jian-Qiang

来源：RSC Advances, 2014, 4(60): 31515-31520.

DOI：10.1039/c4ra04617j

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A simple and effective strategy for the directed and high-yield assembly of large-sized Au NPs has been demonstrated by bithiol-modified complementary dsDNA architectures. The dsDNA architectures were formed by mixing two complementary thiol-modified ssDNA (only 36 bases) and played an important role in the high-yield self-assembly of the large-sized Au NPs. Compared with traditional methods, this strategy was simple, effective, low-cost and enabled excellent self-assembly of large-sized Au NPs, while obviating the need for the conjugate of Au NPs to ssDNA and the use of long chain DNA. Therefore, this straightforward and high efficiency methodology opens a new avenue of DNA-induced self-assembly of large-sized metal NPs.

• 出版日期2014
• 单位广州市疾病预防控制中心; 暨南大学; 华南理工大学