Metal-free visible light driven synthesis of tetrahydroquinoline derivatives utilizing Rose Bengal

作者：Xin, Jing-Rui; Guo, Jun -Tao; Vigliaturo, Dominic; He, Yan-Hong^*; Guan, Zhi^*

来源：Tetrahedron, 2017, 73(31): 4627-4633.

DOI：10.1016/j.tet.2017.06.030

• Visible light
• Photoredox catalysis
• Rose Bengal
• Tetrahydroquinoline
• Tandem radical cyclization

The visible-light driven reaction for the synthesis of tetrahydroquinoline derivatives via tandem radical cyclization of N,N-dimethylanilines with 2-benzylidenemalononitriles has been developed. Corresponding products were obtained with yields of up to 74% under mild conditions by using Rose Bengal as a triplet sensitizer, which is inexpensive, environmentally-friendly and easily acquired. This work demonstrates the potential benefits of Rose Bengal for the production of tetrahydroquinoline derivatives.

• 出版日期2017-8-3
• 单位西南大学