A comprehensive investigation of anti-inflammatory diarylheptanoids from the leaves of Alnus formosana

作者：Lai Yi Chun; Chen Chien Kuang; Lin Wan Wan; Lee Shoei Sheng^*

来源：Phytochemistry, 2012, 73: 84-94.

DOI：10.1016/j.phytochem.2011.02.008

• Alnus formosana
• Betulaceae
• Diarylheptanoids
• HPLC-SPE-NMR
• Anti-inflammatory

This study was aimed to investigate thoroughly the diarylheptanoids in the n-BuOH soluble fraction of leaves of Alnus formosana in order to examine their anti-inflammatory activities. The application of HPLC-SPE-NMR as a preliminary chemical screening led to characterization of eleven compounds. Further separation resulted in isolation of 28 compounds, of which 10 diarylheptanoids and 2-coumaroylxyloside are new natural products. Compound 1 and alnuside A (27) were found to possess good activities against LPS-induced NO production with respective IC50 values of 7.99 and 8.08 mu M, and which were devoid of significant cytotoxicity.

• 出版日期2012-1