Novel function of transthyretin in pancreatic alpha cells

作者：Su Yu; Jono Hirofumi^*; Misumi Yohei; Senokuchi Takafumi; Guo Jianying; Ueda Mitsuharu; Shinriki Satoru; Tasaki Masayoshi; Shono Makoto; Obayashi Konen; Yamagata Kazuya; Araki Eiichi; Ando Yukio

来源：FEBS LETTERS, 2012, 586(23): 4215-4222.

DOI：10.1016/j.febslet.2012.10.025

• Transthyretin
• Glucagon
• Pancreas
• Pancreatic alpha cell
• Glucose homeostasis

Although transthyretin (TTR) is expressed in pancreatic alpha (glucagon) cells in the islets of Langerhans, the function of TTR in pancreatic alpha cells remains unknown. In this study, by using TTR knockout (TTR KO) mice, we determined the novel role of TTR in glucose homeostasis. We demonstrated that TTR KO mice evidenced impaired recovery of blood glucose and glucagon levels. Lack of TTR induced significantly lower levels of glucagon in the islets of Langerhans. These results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon.

• 出版日期2012-11-30