Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

作者：Ma Xing^*; Ong Onn Shaun; Zhao Yanli

来源：Biomaterials Science, 2013, 1(9): 912-917.

DOI：10.1039/c3bm60090d

Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.

• 出版日期2013
• 单位南阳理工学院