Airway compliance and dynamics explain the apparent discrepancy in length adaptation between intact airways and smooth muscle strips

作者：Dowie, Jackson; Ansell, Thomas K.; Noble, Peter B.; Donovan, Graham M.^*

来源：Respiratory Physiology & Neurobiology, 2016, 220: 25-32.

DOI：10.1016/j.resp.2015.09.006

• Airway smooth muscle
• Length adaptation
• Bronchi
• Hyperresponsiveness

Length adaptation is a phenomenon observed in airway smooth muscle (ASM) wherein over time there is a shift in the length-tension curve. There is potential for length adaptation to play an important role in airway constriction and airway hyper-responsiveness in asthma. Recent results by Ansell et al., 2015 (JAP 2014 10.1152/japplphysiol.00724.2014) have cast doubt on this role by testing for length adaptation using an intact airway preparation, rather than strips of ASM. Using this technique they found no evidence for length adaptation in intact airways. Here we attempt to resolve this apparent discrepancy by constructing a minimal mathematical model of the intact airway, including ASM which follows the classic length-tension curve and undergoes length adaptation. This allows us to show that (I) no evidence of length adaptation should be expected in large, cartilaginous, intact airways; (2) even in highly compliant peripheral airways, or at more compliant regions of the pressure-volume curve of large airways, the effect of length adaptation would be modest and at best marginally detectable in intact airways; (3) the key parameters which control the appearance of length adaptation in intact airways are airway compliance and the relaxation timescale. The results of this mathematical simulation suggest that length adaptation observed at the level of the isolated ASM may not clearly manifest in the normal intact airway.

• 出版日期2016-1