A non-resonant microwave applicator fully dedicated to continuous flow chemistry

作者：Fardost Ashkan; Russo Francesco; Larhed Mats^*

来源：Chimica Oggi-Chemistry Today, 2012, 30(4): 14-16.

• Microwave
• continuous flow
• non-resonant
• scale-out
• scale-up
• microwave-assisted organic synthesis
• tubular reactor

The concept of a non-resonant microwave applicator designed for continuous flow chemistry was introduced by our group this year. With a power output of 0 - 150 W, adjustable frequency range of 2.4 - 2.5 GHz and five IR sensors monitoring the temperature along a tubular borosilicate reactor, the instrument ensures fast, efficient and uniform heating. A variety of organic reactions were optimized for continuous flow chemistry using a 200 mm x empty set 3 mm reactor, which proved the instrument to be an unprecedented tool for fast method optimization. A scale-out study is now reported where reactions already optimized in a empty set 3 mm reactor are run in a empty set 6 mm reactor, aiming for a fourfold increase in chemical throughput with no or little need for re-optimization.

• 出版日期2012-8