Potential of radioiodinated anticancer compounds of traditional Chinese medicine for cancer therapy

作者：Yang, Min^*; Xu, Yu-pin; Pan, Dong-hui; Din, Hong; Wang, Li-zhen; Wang, Guang-ji

来源：Journal of Radioanalytical and Nuclear Chemistry, 2010, 283(1): 189-191.

DOI：10.1007/s10967-009-0192-6

• Radio iodination
• Chinese medicine
• Cancer therapy
• Tumor uptake

23-Hydroxybetulinic acid (23-HBA) is the efficient antitumor compound extracted from the roots of a Chinese Medicinal Herb, Pulsatilla chinensis (Bge) Regel. To evaluate the effect of radioiodination on cytotoxicity, 23-HBA was radioiodinated with I-125. I-125-23-HBA could be prepared in high yields and good radiochemical purity and was characterized using reverse phase HPLC. In ICR mice bearing Liver Cancer HepA tumor, I-125-23-HBA showed a tumor uptake of 2.1% ID/g at 2 hp.i. and 0.15% ID/g at 48 hp.i on i.v. injection. When injected intratumorally, greater tumor uptake and retention was observed (20% ID/g at 2 hp.i. and 4.6% ID/g at 48 hp.i. respectively).

• 出版日期2010-1
• 单位江苏省原子医学研究所; 中国药科大学