An Efficient Synthesis of Chromeno[4,3-d]isoxazolo[5,4-b]pyridin-6-one Derivatives

作者：Jin, Pei-Pei; Liu, Xue-Cheng; Liu, De-Qi; Huang, Zhi-Bin; Shi, Da-Qing^*

来源：Journal of Heterocyclic Chemistry, 2015, 52(6): 1625-1630.

DOI：10.1002/jhet.2255

• HIGHLY EFFICIENT
• 3-COMPONENT REACTION
• SUZUKI-MIYAURA
• FLUORESCENCE
• COUMARINS
• POTENT
• DIFFERENTIATION
• COMPLEXES
• CATALYST
• TARGET

A series of chromeno[4,3-d]isoxazolo[5,4-b]pyridin-6-one derivatives were easily and efficiently synthesized by the reaction of 3-acyl-2H-chromen-2-ones with isoxazol-5-amine in acetic acid. Some synthesized compounds were evaluated for their antiproliferative properties in vitro against cancer cells, and these compounds were found to have some activities.

• 出版日期2015-11
• 单位苏州大学