A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride leading to primary arylamines

作者：Huang, Xue; Xiao, Ruian; You, Chongren; Yan, Tao; Cai, Mingzhong^*

来源：Journal of Chemical Research, 2017, 41(6): 315-320.

DOI：10.3184/174751917X14931195075580

• supported copper catalyst
• cascade reaction
• acetamidine hydrochloride
• primary arylamine
• heterogeneous catalysis
• MCM-41

A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride was achieved in DMF in the presence of 10 mol% of an MCM-41-immobilised L-proline-copper(I) complex (MCM-41-L-proline-CuI) with Cs2CO3 as base, yielding a variety of primary arylamines in good to excellent yields. The new heterogeneous copper complex can be easily prepared from commercially readily available and inexpensive reagents, recovered by a simple filtration of the reaction solution and used at least seven more times without any decrease in activity.

• 出版日期2017-6-1
• 单位江西师范大学