Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

作者：Banik Bimal K^*; Banik Indrani; Becker Frederick F

来源：European Journal of Medicinal Chemistry, 2010, 45(2): 846-848.

DOI：10.1016/j.ejmech.2009.11.024

• beta-Lactams
• Anticancer agents
• Asymmetric synthesis
• Carbohydrate
• Staudinger reaction
• In vitro tests

We describe herein asymmetric synthesis of a novel anticancer beta-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these beta-lactams are also reported here.

• 出版日期2010-2