Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats

作者：Fuegl Alexander; Gruber Reinhard; Agis Hermann; Lzicar Hannah; Keibl Claudia; Schwarze Uwe Yacine; Dvorak Gabriella^*

来源：Journal of Clinical Periodontology, 2015, 42(1): 96-103.

DOI：10.1111/jcpe.12342

• 1
• 25(OH)D-3
• bone healing
• calcitriol
• supplementation
• topic administration
• vitamin D deficiency

AimVitamin D deficiency is considered to diminish bone regeneration. Yet, raising the serum levels takes months. A topic application of the active vitamin D metabolite, calcitriol, may be an effective approach. Thus, it becomes important to know the effect of vitamin D deficiency and local application on alveolar bone regeneration.
Material and MethodsSixty rats were divided into three groups; two vitamin depletion groups and a control group. Identical single defects (2mm diameter) were created in the maxilla and mandible treated with calcitriol soaked collagen in one deficiency group while in the other two groups not. Histomorphometric analysis and micro CTs were performed after 1 and 3weeks. Serum levels of 25(OH)D-3 and PTH were determined.
ResultsBone formation rate significantly increased within the observation period in all groups. Bone regeneration was higher in the maxilla than in the mandible. However, bone regeneration was lower in the control group compared to vitamin depletion groups, with no significant effects by local administration of calcitriol (micro CT mandible p=0.003, maxilla p<0.001; histomorphometry maxilla p=0.035, mandible p=0.18).
ConclusionVitamin D deficiency not necessarily impairs bone regeneration in the rat jaw and a single local calcitriol application does not enhance healing.

• 出版日期2015-1