Advantages and Potential of Lipid-Membrane-Incorporating Fullerenes Prepared by the Fullerene-Exchange Method

作者：Ikeda Atsushi^*; Mori Miyuki; Kiguchi Kazuya; Yasuhara Kazuma; Kikuchi Jun ichi; Nobusawa Kazuyuki; Akiyama Motofusa; Hashizume Mineo; Ogawa Takuya; Takeya Tatsuo

来源：Chemistry-An Asian Journal, 2012, 7(3): 605-613.

DOI：10.1002/asia.201100792

• cyclodextrins
• exchange reactions
• fullerenes
• lipids
• photodynamic activities

Lipid-membrane-incorporating C60 and C70 (LMIC60 and LMIC70) were prepared by the fullerene-exchange reaction from the ?-cyclodextrin cavity to vesicles (we call this method the exchange method). An advantage of this method is that the ratios of [C60]/[lipids] and [C70]/[lipids] can be arbitrarily controlled by adjusting the ratios of the fullerenes and liposome. The maximum ratio (30 mol?%) obtained was approximately 14 and 100 times higher than those achieved for LMIC60 and LMIC70, respectively, that were prepared by the classical method, which we call the premixing method (dissolving lipids and C60 or C70 in chloroform, followed by concentration and extraction with water). Furthermore, the stabilities and photodynamic activities of the LMIC60 and LMIC70 solutions prepared by the exchange method were shown to be much higher than those prepared by the premixing method. That is, the exchange method was found to be superior to the premixing method as a preparative method of LMIC60 and LMIC70 for applications in photomedical and photomaterials chemistry.

• 出版日期2012-3-5