A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy

作者：Cheong Jae Youp; Rhee Young Ho^*

来源：Beilstein Journal of Organic Chemistry, 2011, 7: 740-743.

DOI：10.3762/bjoc.7.84

• clavukerin A
• cycloisomerization
• gold catalyst
• hydrogenation
• stereoselectivity

An efficient formal total synthesis of (+/-)-clavukerin A was accomplished via a gold-catalyzed cycloisomerization of a 3-methoxy-1,6-enyne 5 as the key strategy followed by Rh-catalyzed stereoselective hydrogenation of the cycloheptenone 4.

• 出版日期2011-6-1