Association of total iron binding capacity with coronary artery disease

作者：Kang Peipei; Liu Tongtao; Tian Changwei; Zhou Yunping; Jia Chongqi^*

来源：Clinica Chimica Acta, 2012, 413(19-20): 1424-1429.

DOI：10.1016/j.cca.2012.05.018

• Coronary artery disease
• Iron
• Total iron binding capacity
• Meta-analysis

Objective: A case-control study and a meta-analysis were conducted to assess the association between total iron binding capacity (TIBC) and coronary artery disease (CAD) risk.
Methods: A hospital-based case-control study was conducted with 258 CAD cases and 282 healthy controls. Logistic regression was utilized to estimate odds ratio (OR) with 95% confidence interval (CI) and adjust potential confounders. Dose-response relation was investigated between TIBC and CAD risk by dividing TIBC concentration into quartiles. A meta-analysis was performed on the standardized mean difference (SMD) as well as OR.
Results: In our case-control study. TIBC was found associated with decreased CAD risk both in univariate (OR = 0.981, 95% CI = 0.975, 0.986) and multivariate (OR = 0.979, 95% CI = 0.972, 0.986) adjusted logistic regressions. The multivariate-adjusted OR for the highest quartile compared with the lowest quartile was 0.087 (95% Cl = 0.042, 0.181). After sensitivity analysis, the meta-analysis on SMD showed that TIBC was associated with decreased CAD risk (SMD = -0211, 95% CI = -0318, -0.104). The results of pooled measure on OR (OR = 0.970,95% CI = 0.946, 0.995) were consistent with those of SMD analysis.
Conclusion: A weak association was found between TIBC levels and decreased CAD risk, further investigations are necessary to clarify the dose-response relationship.

• 出版日期2012-10-9
• 单位山东大学