A Trinuclear Oxo-Chromium(III) Complex Containing the Natural Flavonoid Primuletin: Synthesis, Characterization, and Antiradical Properties

作者：Alexiou Anamaria D P^*; Decandio Carla C; Almeida Sabrina da N; Ferreira Marcelo J P; Romoff Paulete; Rocha Reginaldo C

来源：Molecules, 2015, 20(4): 6310-6318.

DOI：10.3390/molecules20046310

• antiradical activity
• chromium(III) complexes
• flavonoids
• metal-oxo cluster
• primuletin

A new trinuclear oxo-centered chromium(III) complex with formula [Cr3O(CH3CO2)(6)(L)(H2O)(2)] (L = 5-hydroxyflavone, known as primuletin) was synthetized and characterized by ESI mass spectrometry, thermogravimetry, and H-1-NMR, UV-Vis, and FTIR spectroscopies. In agreement with the experimental results, DFT calculations indicated that the flavonoid ligand is coordinated to one of the three Cr(III) centers in an O,O-bidentate mode through the 5-hydroxy/4-keto groups. In a comparative study involving the uncoordinated primuletin and its corresponding complex, systematic reactions with the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that antiradical activity increases upon complexation.

• 出版日期2015-4