A parallel-group comparison study of celecoxib with loxoprofen sodium in third mandibular molar extraction patients

作者：Yamashita Y^*; Sano N; Shimohira D; Danjo A; Goto M

来源：International Journal of Oral and Maxillofacial Surgery, 2014, 43(12): 1509-1513.

DOI：10.1016/j.ijom.2014.09.002

• celecoxib
• loxoprofen sodium
• post-exodontic pain
• non-steroidal anti-inflammatory drugs
• analgesic effect

Non-steroidal anti-inflammatory drugs (NSAIDs) are used widely, but they may damage the upper gastrointestinal mucosa owing to their mechanism of action. Selective cyclooxygenase 2 (COX-2) inhibitors are known to have a reduced risk for such damage. In this comparative study, the efficacy and safety of the selective COX-2 inhibitor celecoxib for pain after third mandibular molar extraction were compared with those of loxoprofen sodium. This was a parallel-group comparison study; 107 patients who had undergone third mandibular molar extraction were given celecoxib and 102 were given loxoprofen. The level of pain on a visual analogue scale (VAS) 15 min and 30 min after taking the experimental drug decreased over time, with no significant difference between the two groups. The percentage of patients taking a second dose was 64.5% for celecoxib and 80.4% for loxoprofen. The time to second dose was significantly longer for celecoxib (533.5 min) than for loxoprofen (387.4 min). There was no significant difference in the patients%26apos; impression of efficacy between the two groups, with ratings of %26apos;excellent%26apos; and %26apos;good%26apos; for 77.4% in the loxoprofen group and 74.5% in the celecoxib group. These results demonstrate that celecoxib is of equal clinical value to loxoprofen for acute pain after third mandibular molar extraction.

• 出版日期2014-12