Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor

作者：Crombag Hans S^*; Johnson Alexander W; Zimmer Anne M; Zimmer Andreas; Holland Peter C

来源：Learning & Memory, 2010, 17(1): 807-811.

DOI：10.1101/lm.1610510

Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors.

• 出版日期2010-1