Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells

作者：Boiers Charlotta; Carrelha Joana; Lutteropp Michael; Luc Sidinh; Green Joanna C A; Azzoni Emanuele; Woll Petter S; Mead Adam J; Hultquist Anne; Swiers Gemma; Perdiguero Elisa Gomez; Macaulay Iain C; Melchiori Luca; Luis Tiago C; Kharazi Shabnam; Bouriez Jones Tiphaine; Deng Qiaolin; Ponten Annica; Atkinson Deborah; Jensen Christina T; Sitnicka Ewa; Geissmann Frederic; Godin Isabelle; Sandberg Rickard; de Bruijn Marella F T R; Jacobsen Sten Eirik W^*

来源：Cell Stem Cell, 2013, 13(5): 535-548.

DOI：10.1016/j.stem.2013.08.012

In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important line-age-commitment step in mammalian hematopoiesis.

• 出版日期2013-11-7