Antibacterial beta-amyrin isolated from Laurencia microcladia

作者：Abdel Raouf Neveen; Al Enazi Nouf Mohammad; Al Homaidan Ali A^*; Ibraheem Ibraheem Borie Mohammad; Al Othman Monerah Rashed; Hatamleh Ashraf Atef

来源：Arabian Journal of Chemistry, 2015, 8(1): 32-37.

DOI：10.1016/j.arabjc.2013.09.033

• Marine algae
• Laurencia microcladia
• Triterpens
• beta-Amyrin
• Antibacterial activity

The present study aimed to isolate beta-amyrin for the first time from Laurencia microcladia Kutzing distributed at Dahab Coast, Aqaba Gulf, Egypt. The successive extraction of the ethanolic extract of the alga showed that, the petroleum ether extract was the best extractive solvent which contains the isolated active compound. Based on IR, MS, and H-1 NMR analyses, the active principle is proposed to be triterpens having the empirical formula C30H50O with a melting point range 191-194 degrees C. The importance of this study was to draw attention and study the economic importance of different types of marine algae that grow on the Egyptian shores as they contain varying antimicrobial effectiveness. beta-Amyrin obtained in this study from L. microcladia was known for its potent antibacterial activity and commonly used medically in many areas. These results provide evidence, to intensify the study on this L. microcladia to be used as a source of b-amyrin.

• 出版日期2015-1