Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada

作者:Tijet Nathalie; Faccone Diego; Rapoport Melina; Seah Christine; Pasteran Fernando; Ceriana Paola; Albornoz Ezequiel; Corso Alejandra; Petroni Alejandro; Melano Roberto G*
来源:PLos One, 2017, 12(7): e0180347.
DOI:10.1371/journal.pone.0180347

摘要

We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins.

  • 出版日期2017-7-5