Ancient human oral plaque preserves a wealth of biological data

作者:Metcalf Jessica L*; Ursell Luke K; Knight Rob
来源:Nature Genetics, 2014, 46(4): 321-323.
DOI:10.1038/ng.2930

摘要

A new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. The authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen Tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins.

  • 出版日期2014-4