科研之友
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摘要
A mild method for alpha-hydroxylation of N-acyl oxazolidinones by asymmetric radical addition of the 2,2,6,6-tetramethylpiperidine N-oxy (TEMPO) radical to titanium enolates was developed. The high diastereoselectivity and broad scope of the reaction show synthetic utility for the alpha-hydroxylation of substrates that are not tolerant to strongly basic conditions.
- 出版日期2014-1-17
