Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine

作者：Zhou, Chun-Qiong; Yang, Jian-Wei; Dong, Cheng; Wang, Yong-Min; Sun, Bin; Chen, Jin-Xiang; Xu, Ya-Shi; Chen, Wen-Hua^*

来源：Organic and Biomolecular Chemistry, 2016, 14(1): 191-197.

DOI：10.1039/c5ob01723h

• DNA-CLEAVING ACTIVITIES
• PARALLEL G-QUADRUPLEXES
• LIGHT-UP PROBE
• TELOMERIC DNA
• C-MYC
• RECOGNITION SPECIFICITY
• STABILIZING LIGANDS
• THIOFLAVIN T
• C9ORF72 GENE
• ON PROBE

This paper describes the highly selective, sensitive and topology-specific fluorescent sensing of dimeric G-quadruplexes by a polyether-tethered dimeric berberine 1. Compound 1 displays high selectivity for dimeric G-quadruplexes over monomeric ones, and can be lit up by dimeric G-quadruplexes, in particular by the one linked with one TTA subunit. In addition, it shows no effect on the topology or thermal stability of the G-quadruplexes.

• 出版日期2016
• 单位南方医科大学