Antioxidant activity of beta-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species?

作者：Gomes Ana; Costa David; Lima Jose L F C; Fernandes Eduarda^*

来源：Bioorganic & Medicinal Chemistry, 2006, 14(13): 4568-4577.

DOI：10.1016/j.bmc.2006.02.023

• beta-blockers
• cardiovascular disease
• antioxidant activity
• reactive oxygen species
• reactive nitrogen species
• scavenging activity

The therapeutic effects of beta-blockers are normally explained by their capacity to block the beta-adrenoceptors, however, some of the beneficial cardiovascular effects shown by this group of compounds have already been associated with the antioxidant properties that some of them seem to possess. The beta-blockers atenolol, labetalol, metoprolol, pindolol, propranolol, sotalol, timolol, and carvedilol were tested for their putative scavenging activity for ROS (O-2(center dot-), H2O2, HO center dot, HOCl, and ROO center dot) and RNS ((NO)-N-center dot and ONOO-). Some of the studied compounds are effective ROS and/or RNS scavengers, these effects being possibly useful in preventing oxidative damage verified in hypertension as well as in other cardiovascular diseases that frequently emerge in association with oxidative stress.

• 出版日期2006-7-1