A Multicenter Study on Expressions of Vascular Endothelial Growth Factor, Matrix Metallopeptidase-9 and Tissue Inhibitor of Metalloproteinase-2 in Oral and Maxillofacial Squamous Cell Carcinoma

作者：Li, Min; Wang, Zhiying^*; Xing, Yang; Yu, Jin; Tian, Luming; Zhang, Dianming; Xin, Zengxi

来源：Iranian Red Crescent Medical Journal, 2014, 16(3): e13185.

DOI：10.5812/ircmj.13185

• Oral Surgical Procedures
• Carcinoma, Squamous Cell
• Vascular Endothelial Growth Factor A
• Matrix Metalloproteinase 9
• Tissue Inhibitor of Metalloproteinase-2

Background: Vascular endothelial growth factor (VEGF), matrix metallopeptidase-9 (MMP-9) and tissue inhibitor of metalloproteinase-2 (TIMP-2) are potential markers of oral and maxillofacial squamous cell carcinoma (SCC).
Objectives: To explore the association between expression of VEGF, MMP-9 and TIMP-2 in oral and maxillofacial SCC and clinicopathological factors.
Patients and Methods: Immunohistochemical Envision method was used to analyze the expression of VEGF, MMP-9 and TIMP-2 in 54 cases of oral and maxillofacial SCC and the association with clinicopathological factors such as clinical staging and lymphatic metastasis.
Results: Brownish-yellow staining is correlated with positive expression of VEGF, MMP-9 and TIMP-2. Positive expression of VEGF and MMP-9 was correlated with lymphatic metastasis, and their positive expression rates were significantly higher in patients with lymphatic metastasis than those without it (VEGF:x(2) =30.00; P =0.001; MMP-9:x(2) =18.27, P =0.001). The positive expression rate of MMP-9 decreased at earlier clinical stages (P < 0.05). Positive expression of TIMP-2 was correlated with lymphatic metastasis, clinical staging and T classification. The positive rate of TIMP-2 expression in patients with lymphatic metastasis was significantly lower than those without it (x(2) =26.74, P =0.002), which significantly reduced with increasing clinical stage and T classification (P <0.05).
Conclusions: Lymphatic metastasis in patients with oral and maxillofacial SCC is closely related to the positive expression of VEGF, MMP-9 and TIMP-2. MMP-9 and TIMP-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial SCC genes.

• 出版日期2014-3
• 单位锦州医科大学; 辽宁工业大学