A clinicopathological analysis of primary mucosal malignant melanoma

作者：Izumi Daisuke; Ishimoto Takatsugu; Yoshida Naoya; Nakamura Kenichi; Kosumi Keisuke; Tokunaga Ryuma; Sugihara Hidetaka; Sawayama Hiroshi; Karashima Ryuichi; Imamura Yu; Ida Satoshi; Hiyoshi Yukiharu; Iwagami Shiro; Baba Yoshifumi; Sakamoto Yasuo; Miyamoto Yuji; Watanabe Masayuki; Baba Hideo^*

来源：Surgery Today, 2015, 45(7): 886-891.

DOI：10.1007/s00595-014-1041-y

• Primary mucosal malignant melanoma
• CXCL12
• CXCR4

Primary mucosal malignant melanoma (PMMM) is a rare and highly lethal neoplasm associated with a poor prognosis. CXC chemokine receptor 4 (CXCR4) is expressed on various tumor cells, including malignant melanoma. Recent data indicate that CXCL12 and CXCR4 play a critical role in the behavior of cancer cells and in the survival of cancer patients. However, there has been no study that has addressed the expression and function of CXCR4/CXCL12 signaling in PMMM.
Immunohistochemical staining for CXCL12 and Ki67 in biopsy tissues from 10 cases of PMMM was performed. We analyzed the correlations between the clinicopathological features and expression levels of CXCL12 and Ki67.
Six cases showed a high level of CXCL12 expression, while four cases had a low level of expression. High expression of CXCL12 correlated with a poor prognosis, although statistical significance was not reached (p = 0.054). Ki67 was highly expressed in five cases, while the expression in the other five cases was low. There was no correlation between the Ki67 expression and prognosis.
The findings of this study suggest that CXCL12 expression may play an important role in the biological behavior of PMMM and may be associated with a poor prognosis of PMMM patients.

• 出版日期2015-7
• 单位中国医学科学院肿瘤医院