An ortho-directed C-H borylation/Suzuki coupling sequence in the formation of biphenylbenzylic amines

作者：Hale Lillian V A^*; Emmerson David G; Ling Emma F; Roering Andrew J; Ringgold Marissa A; Clark Timothy B

来源：Organic Chemistry Frontiers, 2015, 2(6): 661-664.

DOI：10.1039/c4qo00348a

A C-H borylation/Suzuki-Miyaura coupling sequence is reported using benzylic amines to direct the C-H borylation to the ortho C-H bond. Both aryl bromides and iodides were coupled to the resulting arylboronate esters. A series of biphenylbenzylic amines are reported, requiring a single purification in the two-step reaction sequence.

• 出版日期2015