Descriptive epidemiology of cholangiocarcinoma in Italy

作者：Alvaro Domenico^*; Crocetti Emanuele; Ferretti Stefano; Bragazzi Maria Consiglia; Capocaccia Riccardo

来源：Digestive and Liver Disease, 2010, 42(7): 490-495.

DOI：10.1016/j.dld.2009.10.009

• Cholangiocarcinoma
• Epidemiology
• Incidence
• Italy
• Mortality

Background: Very little data exist on the epidemiology of cholangiocarcinoma in Italy.
Aim: We focus on the descriptive epidemiology of cholangiocarcinoma in Italy.
Methods: Data on incidence were obtained from the Italian Association of Tumour Registries while mortality data were obtained from the Italian National Institute of Statistics.
Results: A progressive increase of incidence with age was seen for extra-hepatic, intra-hepatic and not otherwise specified cholangiocarcinoma. Crude incidence rates were higher for extra-hepatic cholangiocarcinoma than those for intra-hepatic cholangiocarcinoma and in men compared to women. An increasing incidence trend was observed, from 1988 to 2005, for both extra-hepatic- and intra-hepatic cholangiocarcinoma with a 3-6% yearly increase and with a rate of increase higher for men than for women and for intra-hepatic- than for extra-hepatic cholangiocarcinoma. For intra-hepatic cholangiocarcinoma, the mortality rates progressively increased from 0.15 per million in 1980 to 5.9 per million in 2003, when mortality for this cancer surpassed extra-hepatic cholangiocarcinoma. Mortality rates for extra-hepatic cholangiocarcinoma showed an increasing trend from 1980 to 1994 but, in contrast to intra-hepatic cholangiocarcinoma, a stable or slightly decreasing trend from 1995 to 2003 was observed.
Conclusions: In Italy, cholangiocarcinoma showed a progressive increase in incidence and mortality in the last two decades mainly in intra-hepatic cholangiocarcinoma.

• 出版日期2010-7