Molecular activation of NF-kappa B, pro-inflammatory mediators, and signal pathways in gamma-irradiated mice

作者：Ha Young Mi; Chung Sang Woon; Kim Ji Min; Kim Dae Hyun; Kim Ji Young; Lee Eun Kyeong; Lee Jaewon; Kim Young Jin; Yoo Mi Ae; Jeong Kyu Shik; Chung Hae Young^*

来源：Biotechnology Letters, 2010, 32(3): 373-378.

DOI：10.1007/s10529-009-0165-4

• Inflammation
• NF-kappa B
• Oxidative stress
• gamma-Irradiation
• Signaling

The effects of gamma-irradiation on inflammatory gene expression, including NF-kappa B activation, in the kidney of C57/BL6 mice exposed to 1-9 Gy doses of (60)Co gamma-irradiation. Radiation enhanced the NF-kappa B activation and oxidative stress caused a dose-dependent disruption in the redox balance. The significance of this study is the new molecular information gained on gamma-irradiation effects through the activation of pro-inflammatory genes by NF-kappa B via the MAPK signaling pathway. Considering the exquisite sensitivity of NF-kappa B and other pro-inflammatory mediators to the redox status, we conclude that the activation of inflammatory processes by irradiation is likely initiated by increased oxidative stress.

• 出版日期2010-3