科研之友
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摘要
In 2007 Martin Evans, Mario Cappecchi and Olivier Smithies were granted Nobel Prize in Physiology in Medicine. Martin Evans was the first who isolated mouse pluripotent embryonic stem cells (ES cells). Cappecchi and Smithies received the prize for the discovery of the methods allowing efficient genetic modification of ES cells. The current review briefly summarizes the history of ES cells, methods of their in vivo and in vitro differentiation and selected issues of their potential application in the therapy. It also focuses on the techniques of genetic modification of ES cells and studies devoted to the derivation of pluripotent stem cells form other then embryonic sources.
- 出版日期2008
