A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappa B activation in colorectal adenocarcinorna

作者：Fang Changming; Dean Jarrod; Smith Jeffrey W^*

来源：Cancer Research, 2007, 67(19): 9039-9046.

DOI：10.1158/0008-5472.CAN-06-3690

Ileal bile acid binding protein (IBABP) is the only cytosolic protein known to bind and transport bile acids. Because IBABP is reportedly up-regulated in colorectal cancer, it has been suggested as a link between bile acids and the risk of colorectal cancer. However, in this study, we show that IBABP is not up-regulated. Rather, a novel transcript of the IBABP gene, which encodes an additional 49 NH2-terminal amino acid residues, is up-regulated in colorectal cancer (P < 0.001). The novel transcript, called IBABP-L, is also distinct from IBABP because its transcription is controlled by nuclear factor-kappa B (NF-kappa B) rather than by the farnesoid X receptor. Most significantly, IBABP-L is necessary for the survival of HCT116 colon cancer cells in the presence of physiologic levels of the secondary bile acid deoxycholate. Collectively, the studies point toward a unique bile acid response pathway involving NF-kappa B and IBABP-L that could be useful for diagnosis and could potentially be targeted for therapeutic benefit.

• 出版日期2007-10-1
• 单位河北医科大学