Update on Breast Cancer Detection Using Comb-Push Ultrasound Shear Elastography

作者：Denis Max; Bayat Mahdi; Mehrmohammadi Mohammad; Gregory Adriana; Song Pengfei; Whaley Dana H; Pruthi Sandhya; Chen Shigao; Fatemi Mostafa; Alizad Azra

来源：IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2015, 62(9): 1644-1650.

DOI：10.1109/TUFFC.2015.007043

In this work, tissue stiffness estimates are used to differentiate between benign and malignant breast masses in a group of pre-biopsy patients. The rationale is that breast masses are often stiffer than healthy tissue; furthermore, malignant masses are stiffer than benign masses. The comb-push ultrasound shear elastography (CUSE) method is used to noninvasively assess a tissue's mechanical properties. CUSE utilizes a sequence of simultaneous multiple laterally spaced acoustic radiation force (ARF) excitations and detection to reconstruct the region of interest (ROI) shear wave speed map, from which a tissue stiffness property can be quantified. In this study, the tissue stiffnesses of 73 breast masses were interrogated. The mean shear wave speeds for benign masses (3.42 +/- 1.32 m/s) were lower than malignant breast masses (6.04 +/- 1.25 m/s). These speed values correspond to higher stiffness in malignant breast masses (114.9 +/- 40.6 kPa) than benign masses (39.4 +/- 28.1 kPa and p < 0.001), when tissue elasticity is quantified by Young's modulus. A Young's modulus >83 kPa is established as a cut-off value for differentiating between malignant and benign suspicious breast masses, with a receiver operating characteristic curve (ROC) of 89.19% sensitivity, 88.69% specificity, and 0.911 for the area under the curve (AUC).

• 出版日期2015-9