A multiplexed nucleic acid microsystem for point-of-care detection of HIV co-infection with MTB and PCP

作者：Xu Lingjia; Kong Jilie^*

来源：Talanta, 2013, 117: 532-535.

DOI：10.1016/j.talanta.2013.08.056

• Human immunodeficiency virus (HIV)
• M. tuberculosis (MTB)
• Pneumocystis carinii pneumonia (PCP)
• Microfluidics Loop-mediated isothermal amplification (LAMP)

Many individuals infected with the human immunodeficiency virus (HIV), especially children in African countries, die of co-infections with Mycobacterium tuberculosis (MTB) (coinfection rate: 50%) or Pneumocystis carinii pneumonia (PCP) (coinfection rate: 81%). The present proposal describes a rapid, portable, low-cost, multiplexed point-of-care diagnostic technique for simultaneously detecting HIV, MTB, and PCP. This technique incorporates a creative micro-device (hardware) and a loop-mediated isothermal amplification strategy (software).

• 出版日期2013-12-15
• 单位复旦大学