Establishing the standard method of cochlear implant in Rongchang pig

作者：Chen, Wei; Yi, Haijin; Zhang, Liang; Ji, Fei; Yuan, Shuolong; Zhang, Yue; Ren, Lili; Li, Jianan; Chen, Lei; Guo, Weiwei; Yang, Shiming^*

来源：Acta Oto-Laryngologica, 2017, 137(5): 503-510.

DOI：10.1080/00016489.2016.1267406

• Cochlear implant
• Rongchang pig
• ABR
• EABR

Conclusions: In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic. @@@ Objective: The aim of this study was to establish a standard method of cochlear implant in a large mammal-pig. @@@ Methods: Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf+/+) and mutation group with hearing loss (Mitf -/-). Cochlear implants were used and ABR and EABR were recorded. The implanted electrodes were observed by X-ray and HE stains. @@@ Results: The success with cochlear implant and the best electrode position could be defined in all animals, the coiling of the cochlea reached 1.5-1.75 turns. Immediately after the operation of cochlear implants, the ABR threshold of the operated ear (right) could not be derived for each frequency at 120dB SPL. Moreover, 7 days after surgery, the low-frequency ABR threshold of the operated ear (right) could be derived partly at 100dB SPL, but the high-frequency ABR threshold could not be derived at 120dB SPL. Immediately or 1 week after cochlear implants, the EABR threshold was 90CL in the Mitf +/+ group. This was obviously lower than the 190CL in the Mitf -/- group.

• 出版日期2017-5
• 单位中国人民解放军空军总医院; 中国人民解放军总医院; 清华大学; 重庆市畜牧科学院