A study on accumulation of magnetic drug in the capillary vessel of target organ using superconducting MDDS

作者：Mishima F^*; Akiyama Y; Nishijima S

来源：Physica C-Superconductivity and Its Applications, 2010, 470(20): 1837-1840.

DOI：10.1016/j.physc.2010.05.218

• Magnetic force
• Ferromagnetic particle
• Superconducting magnet
• Cow
• Corpus luteum
• Capillary vessel model

Magnetic Drug Delivery System (MDDS) is one of the drug therapy technologies to accumulate the drug at the targeted part efficiently. The ferromagnetic particle is attached to the medicine, antibody, hormones and so on. The magnetic seeded drug is injected into the blood vessel, and then is accumulated in capillary vessel of target organ by magnetic field generated by the superconducting magnet placed outside of the body. The technology is great prospective for not only human medical treatment but also stockbreeding field. Treatment for cow ovarian diseases (decay of ovarian hormone secretion) requires an improvement in suppression of the drug diffusion to non-diseased part by the blood flow. In order to solve the problem, the applicability of the MDDS was examined. The behavior of the magnetic drug under the magnetic field generated by high temperature superconducting (HTS) bulk magnet were studied by the model experiment and computer simulation with the capillary model of the corpus luteum. As a result, it was shown that MDDS is able to apply to the capillaries of the corpus luteum (yellow body).

• 出版日期2010-11-1