Antiproliferative Activity of trans-Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells

作者：Cebrian Torrejon Gerardo; Kahn Suzana Assad; Lagarde Nathalie; Castellano Flavia; Leblanc Karine; Rodrigo Jordi; Molinier Frenkel Valerie; de Arias Antonieta Rojas; Ferreira Maria Elena; Thirant Cecile; Fournet Alain; Figadere Bruno; Chneiweiss Herve; Poupon Erwan^*

来源：Journal of Natural Products, 2012, 75(2): 257-261.

DOI：10.1021/np2004165

Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.

• 出版日期2012-2