Analysis of the genetic constructs expressing antiviral siRNAs in the non-viral test system

作者：Alembekov I R^*; Kretova O V; Churikov N A

来源：Voprosy Virusologii, 2011, 56(2): 32-35.

The efficiency of RNA interference triggered by the genetic constructs encoding siRNAs and directed against human immunodeficiency virus type 1 (HIV-1) transcripts was investigated in the non-viral test system. The investigation showed 6 biologically active siRNAs attacking 6 conservative targets in the HIV-1 genome. Expression of these genetic constructs failed to induce a nonspecific interferon response.

• 出版日期2011-4