An efficient synthesis of novel chromeno[3′,4′:5,6]pyrano[2,3-b]indole derivatives

作者：Chen, Zhi-Wei; Zhang, Na; Wang, Zhi-Hua; Su, Wei-Ke^*

来源：Chinese Chemical Letters, 2013, 24(3): 199-201.

DOI：10.1016/j.cclet.2013.01.033

• Pyranochromene
• Indolin-2-one
• 4-Hydroxycoumarin
• Multicomponent reaction
• Intramolecular cyclization

An efficient two-step method was described for the synthesis of chromeno[3',4':5,6]pyrano[2,3-b]indole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P2O5 in refluxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCl3.

• 出版日期2013-3
• 单位浙江工业大学