Associations between human herpesvirus-6, human papillomavirus and cervical cancer

作者：Amirian E Susan; Adler Storthz Karen; Scheurer Michael E^*

来源：Cancer Letters, 2013, 336(1): 18-23.

DOI：10.1016/j.canlet.2013.04.023

• Cervical cancer
• Human papillomavirus
• Human herpesvirus 6

Cervical cancer (CxCa) is the second most common cancer among women globally. Human papillomavirus (HPV) infection is thought to be a necessary, but not sufficient, causal factor in CxCa development. Why some women are able to clear HPV infection with no adverse effects, whereas others develop cancer, remains unclear. HHV-6 has demonstrated transformative abilities and has been shown to be present in the genital tract. However, based on the current evidence, we cannot conclude that HHV-6 is a co-factor in HPV-associated carcinogenesis. Nonetheless, future research is warranted because of several crucial gaps in the literature.

• 出版日期2013-8-9