Assessment of Pulmonary Neutrophilic Inflammation in Emphysema by Quantitative Positron Emission Tomography

作者：Subramanian Deepak R; Jenkins Lee; Edgar Ross; Quraishi Nabil; Stockley Robert A; Parr David G^*

来源：American Journal of Respiratory and Critical Care Medicine, 2012, 186(11): 1125-1132.

DOI：10.1164/rccm.201201-0051OC

• alpha(1)-antitrypsin deficiency
• fluorodeoxyglucose F18
• neutrophil
• computed tomography

Rationale: Neutrophilic inflammation is understood to be of pathogenetic importance in chronic obstructive pulmonary disease (COPD) and may be quantified using 18-fluorodeoxyglucose positron emission tomography computed tomography ((18)FDG PET-CT) as a noninvasive, spatially informative biomarker.
Objectives: To assess the potential usefulness of (18)FDG PET-CT as a surrogate measure of pulmonary neutrophilic inflammation in patients with usual COPD and alpha(1)-antitrypsin deficiency (AATD).
Methods: (18)FDG PET-CT imaging was performed in 10 patients with usual COPD, 10 patients with AATD, and 10 healthy control subjects. Pulmonary (18)FDG uptake was estimated by three-dimensional Patlak graphical analysis as an indicator of pulmonary neutrophilic glycolytic activity. Patient; with AATD were treated with 12 weekly intravenous infusions of AAT augmentation therapy before repeat imaging. (18)FDG uptake, lung physiology, lung density, and systemic markers of inflammation were compared for all groups at baseline and, in patients with AATD, at baseline and on treatment. Measurements and Main Results: (18)FDG uptake in the upper lung of patients with usual COPD was greater compared with the healthy control group (P = 0.009) and correlated with measures of disease severity (FEV1% predicted, r = -0.848, P = 0.001; FEV1/FVC, r = -0.918, P < 0.001; Kco% predicted, r = -0.624, P = 0.027; 15th percentile point, r = -0.709, P = 0.011). No significant difference was observed between measurements at baseline and on treatment in patients with AATD.
Conclusions: Quantitative (18)FDG PET-CT has a potential role as an imaging biomarker in mechanistic and interventional studies in patients with usual COPD. The data support previous evidence of distinct functional characteristics of neutrophils in COPD.

• 出版日期2012-12-1