A convergent synthesis of the macrolide core of migrastatin

作者：Baba V Sai; Das Parthasarathi^*; Mukkanti K; Iqbal Javed

来源：Tetrahedron Letters, 2006, 47(34): 6083-6086.

DOI：10.1016/j.tetlet.2006.06.082

We describe an efficient synthesis of the 14-membered macrolide core 2 of migrastatin via key intermediate 3 employing a diastereoselective aldol condensation, Lewis acid mediated diastereoselective addition and an exclusive (Z)-olefination sequence. Yamaguchi esterification of the key intermediate 3 followed by ring-closing metathesis (RCM) produced macrolide 2 with high selectivity and good yield.

• 出版日期2006-8-21