科研之友
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摘要
A series of functionalized furans were synthesized by way of a palladium -catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of BuAd(2)P and t-BuOK in DMF at 120 degrees C after 15 h.
